8β,12α-17-Phenyl-18,19,20-trinor-PGF2.sub.α compounds

ABSTRACT

This invention is a group of 8-beta, 12-alpha-PG 2  (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.

CROSS REFERENCE TO RELATED APPLICATIONS

This is a division of application Ser. No. 374,405, filed June 28, 1973,which is a continuation-in-part of my copending application Ser. No.289,317 filed Sept. 15, 1972, now abandoned.

The present invention relates to prostaglandin analogs, for which theessential material constituting a disclosure thereof is incorporated byreference here from Ser. No. 518,436, filed Oct. 29, 1974, now pendingissuance as a U.S. Patent.

I claim:
 1. An optically active compound of the formula ##SPC1##WhereinR₄, r₅, and R₇ are hydrogen or methyl, being the same or different;Wherein R₁₃ is hydrogen, alkyl of one to 12 carbon atoms, inclusive,cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbonatoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloroor alkyl of one to 4 carbon atoms, inclusive; and Wherein s is zero,one, 2, or 3; including the lower alkanoates thereof, and thepharmacologically acceptable salts thereof when R₁₃ is hydrogen. 2.17-(P-CHLOROPHENYL)-18,19,20-TRINOR-8β,12α-PGF₂.sub.α, a compoundaccording to claim
 1. 3.17-(P-CHLOROPHENYL)-18,19,20-TRINOR-8β,12α-PGF₂.sub.α, methyl ester, acompound according to claim
 1. 4.17-Phenyl-18,19,20-trinor-8β,12α-PGF₂.sub.α, a compound according toclaim
 1. 5. 17-Phenyl-18,19,20-trinor-8β,12α-PGF₂.sub.α, methyl ester, acompound according to claim
 1. 6. A optically active compound of theformula ##SPC2##Wherein R₄ R₅, and R₇ are hydrogen or methyl, being thesame or different; Wherein R₁₃ is hydrogen, alkyl of one to 12 carbonatoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkylof 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted withone, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive; andWherein R₂₂ is alkyl of one to 4 carbon atoms, inclusive; Wherein s iszero, one, 2, or 3;Including the lower alkanoates thereof, and thepharmacologically acceptable salts thereof when R₁₃ is hydrogen.